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Memory capabilities decline with age, evident in human degenerative diseases such as Alzheimer's disease, which is accompanied by an accumulation of oxidative damage. CPAs have been met with mixed reviews by physicians and physician advocacy groups. Various other carbamates have been found to share these effects, such as tybamate and lorbamate. In place since March 2001, a total of thirty-one countries are currently organized participants in the program in addition to regional participants. For patients 65 years and older, unclear if there is a difference in response.

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